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Neuroprotective effect of mitochondrial translocator protein …
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WebRo5-4864 and PK11195, prototypical synthetic ligands of translocator protein 18 kDa (TSPO), have shown anti-inflammatory effects in several models of inflammatory diseases; however, their biochemical mechanisms remain poorly understood. Nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasomepyrin domain containing 3 (NLRP3) WebFinally, we showed that PK11195, a pharmacological inhibitor of the cholesterol translocator TSPO, embedded in Mitochondria-Associated Membranes, exerts a synergetic effect with mitotane in inducing Mitochondria-Associated Membranes disruption, ... ATAD3A or TSPO were greatly reduced by mitotane as assessed by western blot analyses. WebMy project involved drug discovery and structure-affinity relationship studies using cell culturing techniques, western blots, ELISAs, immunofluorescent imaging and cell viability … bippity boppity