Topoisomerase 2a
WebThe aim of the present study was to determine the role of topoisomerase 1 (TOP1) and topoisomerase 2A (TOP2A) in liver cancer (LC), and to investigate the inhibitory effect of … WebNov 15, 2011 · The HER2 amplicon on chromosome 17q is variable in size and occasionally includes Topoisomerase 2A (TOP2A) at 17q21-22. It has been suggested that TOP2 co-amplification, not HER2 amplification on …
Topoisomerase 2a
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WebSep 1, 2024 · DNA topoisomerase 2, which is ubiquitously expressed in eukaryotic cells, is an essential nuclear enzyme that promotes cell survival by regulating DNA topology and … WebJun 5, 2024 · Topoisomerase activities that modulate supercoiling and knotting of intracellular DNA. (A) Both topo I and topo II can relax the (+)S and (−)S of DNA generated, respectively, in front of and behind the transcribing complex.The DNA-swiveling mechanism of topo I performs nearby the RNA polymerase, whereas the DNA cross-inversion …
WebSpecifically, the interaction of NELFA with DNA topoisomerase 2a (Top2a) is essential for NELFA to activate Dux; Dux will be silenced in Top2a-deficient cells even when NELFA is overexpressed . The role of NELFA remains controversial, as other studies indicate that NELFA is a direct target of DUX rather than a driver of Dux . More data from ... WebThis gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and …
WebHome; About. Mission Statement / Core Values; History; Membership Info; Schools. A – F; G – L; M – T; U – Z; Conferences; Classifications; Divisions; Regions ... WebSep 1, 2024 · DNA topoisomerase 2, which is ubiquitously expressed in eukaryotic cells, is an essential nuclear enzyme that promotes cell survival by regulating DNA topology and chromatid separation. This enzyme has been validated as a target for anticancer agent screening. It can be poisoned by common chemotherapeutics, such as etoposide and …
WebJun 17, 2009 · Type II topoisomerases are ubiquitous enzymes that play an essential role in the control of replicative DNA synthesis and share structural and functional homology among different prokaryotic and eukaryotic organisms. Antibacterial fluoroquinolones target prokaryotic topoisomerases at concentrations 100- to 1000-fold lower than mammalian …
WebJan 10, 2024 · Topoisomerase I (TOP1) relaxes both positive and negative supercoils by nicking DNA and after rotation of the broken DNA strand closes the nick. Here, the authors present the DNA free crystal ... moncton press clubWebMar 29, 2024 · Topoisomerase: A class of enzymes that alter the supercoiling of double-stranded DNA. (In supercoiling the DNA molecule coils up like a telephone cord, which … moncton population projectionsWebDas KMT2A-Gen (Lysin-Methyltransferase 2A) an 11q23.3 ist üblicherweise bei akuten Leukämien, insbesondere bei Säuglingsleukämie und bei sekundärer Leukämie, nach Behandlung mit DNA-Topoisomerase-II-Inhibitoren neu angeordnet1. Das KMT2A-Gen weist eine große Homologie mit dem Drosophila-Trithorax-Gen moncton population 2021WebApplications. Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 174 kDa. Use a concentration of 0.5 - 1 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. (Primary incubation for 30 min at RT). Use at an assay dependent concentration. moncton provincial court officeWebAll lanes : Anti-Topoisomerase II alpha antibody [EP1102Y] (ab52934) at 1/1000 dilution Lane 1 : HeLa (human cervix adenocarcinoma) whole cell lysate Lane 2 : Jurkat (human … moncton projectsWebMar 19, 2024 · Top2cc was detected using the Human Topoisomerase ICE Assay Kit (Cat #TG1020-2a; Topogen). The method of DNA purification was modified by combining the … ibps in admit cardWebApr 7, 2015 · Topoisomerase 2A (TOP2A), the key enzyme required for generating transient double-stranded breaks in DNA topological structure, played a significant role in DNA replication and transcription and the … ibps in com