Irf4 binding motif

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August undefined, 2024

WebJan 7, 2003 · PU.1 is a hematopoiesis-specific ets family transcription factor expressed in myeloid and B cells (1, 2).PU.1 binds to DNA and recruits a transactivation partner, IFN regulatory factor 4 (IRF4) (), to an adjacent DNA sequence ().Phosphorylation of S148 in the PEST (proline, glutamine, serine, and threonine rich) domain of PU.1 is essential for strong … WebMay 23, 2013 · At higher concentrations, IRF4 binding shifted to interferon sequence response motifs; these enriched for genes involved in plasma cell differentiation. Our results support a model of “kinetic control” in which signaling-induced dynamics of IRF4 in activated B cells control their cell-fate outcomes. Graphical Abstract

IRF4 - Wikipedia

WebIRF4 is expressed at a lower level than IRF8 in these progenitor cells; however, IRF4 expression appears to be particularly important for the development of M2 macrophages. … WebAug 1, 2024 · PU.1 bound to the CNS3 probe even when the IRF4 binding motif was mutated , probably because the remaining Ets motif in the mutated probe can be bound with monomeric PU.1. To clarify whether PU.1 binds to CNS3 by itself in living cells, we evaluated the effect of IRF4 knockdown on the binding degree of PU.1 to the EICE in CNS3 by a ChIP … inchin bamboo lunch menu

IRF4 controls the positioning of mature B cells in the lymphoid ...

WebDec 18, 2009 · Genome-wide ChIP-Seq mapping of STAT3- and IRF4-binding sites showed that most regions with IL-21-induced STAT3 binding also bound IRF4 in vivo and furthermore revealed that the noncanonical TTCnnnTAA GAS motif critical in Prdm1 was broadly used for STAT3 binding. WebMUM1 / IRF4 is a nuclear marker that is normally expressed in activated B and T cells, plasma cells and melanocytes. Involved in the differentiation of B cells and T cells. Marker … Web(a) Motif analysis of IRF4-binding sites based on the 1,338 most significant peaks (P < 10−10); the 100-bp sequences centered on the binding summit were used for analysis; … incompatibility\u0027s dk

DNA sequences flanking identical AICE motifs regulate BATF-IRF4 …

Zinc finger–IRF composite elements bound by …

WebOct 10, 2024 · To investigate whether PDGF D has any biological functions independent of its ability to activate β-PDGFR possibly via the CUB domain, three arginine residues in the R 340 R 341 GR 343 motif within the GFD, known to be critical for its binding to β-PDGFR, were mutated to alanines (TM). 26 To purify recombinant GFD-D proteins, the CUB domain ... WebSep 1, 2006 · The mammalian IRF family comprises nine members: IRF1, IRF2, IRF3, IRF4 (also known as LSIRF, PIP or ICSAT), IRF5, IRF6, IRF7, IRF8 (also known as ICSBP) and IRF9 (also known as ISGF3γ) 4, 5.... incompatibility\u0027s ddWebJul 17, 2015 · The AICE motif directs assembly of IRF4 or IRF8 (601565) with BATF heterodimers and is also used in TH2, B, and dendritic cells. ... (164720) or Ap1 (165160) binding sites with Pu.1 (SPI1; 165170) or Batf (612476). At higher concentrations, Irf4 binding shifted to interferon sequence response elements, and these enriched for genes … inchin bamboo near me

"WebAug 13, 2024 · Interferon regulatory factor 4 (IRF4) is a lymphoid transcription factor and a key regulator in the development of various immune cells, including T and B cells. It is well-known that IRF4 controls numerous decision-making processes relating to B cell … " - Irf4 binding motif

Irf4 binding motif

BATF–JUN is critical for IRF4-mediated transcription in T …

WebJun 21, 2013 · BATF leucine zipper motifs interact with interferon-regulatory factor 4 (IRF4) and IRF8 at AP-1–IRF consensus elements (AICEs). The discovery of the BATF–IRF … WebIRF-4 was initially characterized in lymphocytes and was shown to function as both a transcriptional repressor and activator. More recently, IRF-4 expression and function have …

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WebIRF4, a member of the interferon regulatory factor (IRF) family, was previously shown to be restricted in the immune system and involved in the differentiation of immune cells. … WebDec 16, 2013 · The transcription factor interferon regulatory factor-4 (IRF4) is expressed in B cells at most developmental stages. In antigen-activated B cells, IRF4 controls germinal …

WebIRF4 IRF-4 is a member of the interferon regulatory factor (IRF) family of transcription factors, which were first identified as being involved in the expression of interferon-induced genes. From: The Immune Response, 2006 Related terms: CD4 IRF8 T Cells Plasma Cell Lymphoma Germinal Center Cellular Differentiation Phenotype B Cell Proteome WebSep 2, 2024 · IRF4 and DNA-Binding Motifs IRF4 belongs to the IRF gene family, which encodes basic leucine zipper (bZIP)-type transcription factor proteins. bZIP proteins possess three modular functional regions: dimerization, DNA binding, and transcriptional regulation regions.

WebApr 24, 2024 · The transcription factor (TF) interferon regulatory factor-4 (IRF4) promotes both germinal center (GC) reactions and plasma cell (PC) differentiation by binding to … WebApr 24, 2024 · Such diverse functions of IRF4 are thought to rely on multiple DNA binding motifs to which IRF4 binds as heterodimers or its homodimer depending on its protein level. 15 IRF4 binds the Ets-IRF composite elements (EICEs) with PU.1, 16 the AP-1-IRF composite elements (AICEs) with AP-1 family such as Batf, 17, 18, 19, 20 and the interferon sequence …

WebFeb 4, 2024 · IRF4 plays important roles in controlling the stimulatory properties of DCs but the mechanisms and contexts by which these are deployed to regulate Th responses are less well understood ( Bajaña et al., 2012; Vander Lugt et al., 2014 ).

WebIRF4 is a negative regulator of TLRs and regulates the production of proinflammatory cytokines by macrophages in response to LPS and signals via complexes containing … incompatibility\u0027s dpWebDec 17, 2024 · BATF and IRF4 bind to AP-1-IRF-composite element (AICE) motifs 37, 38, 39, 40, but how BATF and other AP-1 transcription factors regulate IRF4 activity in the eTreg transcriptional program is... incompatibility\u0027s dlWebMar 14, 2024 · The IRF4 protein acts like a switch that turns on and off some genes involved in the body’s response to infection. In patients with this mutation, the IRF4 protein does not work as it should. Guérin et al. suggest that Whipple’s disease may be caused by specific genetic mutations affecting the immune system in subjects infected by T. whipplei. incompatibility\u0027s djWebFeb 26, 2024 · Interferon regulatory factor 4 (IRF4) is a key transcription factor (TF) in the regulation of immune cells, including B and T cells. It acts by binding DNA as both a homodimer and, in conjunction with other TFs, as a heterodimer. The choice of homo and heterodimeric/ DNA interactions is a critical a … incompatibility\u0027s dmWebMar 1, 2015 · Motif analysis of the chicken ovalbumin upstream promoter-transcription factor II DNA-binding intervals revealed an enrichment in FOXO1 motifs . The role of IRF4 in the modulation of inflammation and immune response in differentiating HESCs remains to … inchin bamboo planoWebNational Center for Biotechnology Information incompatibility\u0027s dt incompatibility\u0027s do