Downregulated genes in cancer
WebNational Center for Biotechnology Information WebJul 30, 2024 · It has been reported that hundreds of tumour suppressor genes are downregulated in breast cancer (40, 41). For instance, the expression of GPER1 is lower in breast cancer patients compared to normal tissues, confirming that GPER1 establishes a pattern of tumour suppressor (42, 43), which can inhibit breast cancer growth and …
Downregulated genes in cancer
Did you know?
WebJun 17, 2024 · Differential Analysis Selected 1,606 Upregulated Genes and 1,964 Downregulated Differentially Expressed Genes The cervical cancer gene expression profile was collected from TCGA database, including 304 cervical cancer tumor tissues and three normal tissues. WebOct 18, 2024 · Survival analysis identified three key genes, CEACAM5, CEACAM6 and CLCA4, that were closely related to HNSCC prognosis. The Oncomine database, qRT–PCR and IHC verified that all 3 key genes were downregulated in most HNSCC tissues compared to adjacent normal tissues. Conclusions
WebOct 6, 2024 · According to the AUC scores, HOXD9 was the most significantly downregulated transcriptional factor, which regulated the expressions of 14 genes, while SPI1 and RUNX1 were the most significantly... WebResults: In total, 428 common DEGs were identified, including 143 upregulated and 285 downregulated. GO and KEGG pathway enrichment analysis indicated that the …
WebSep 7, 2024 · We also identified 3152 DEGs, including 514 upregulated and 2638 downregulated genes in the glycolysis-highest group compared to the glycolysis-low … WebDownregulation or upregulation of an RNA or protein may also arise by an epigenetic alteration. Such an epigenetic alteration can cause expression of the RNA or protein to …
WebApr 14, 2024 · Histone acetylation plays a vital role in organizing chromatin, regulating gene expression and controlling the cell cycle. The first histone acetyltransferase to be identified was histone acetyltransferase 1 (HAT1), but it remains one of the least understood acetyltransferases.
WebApr 9, 2024 · MiR-370-3p, downregulated in bladder cancer, was sponged by breast cancer anti-estrogen resistance 4 (BCAR4) ... C.H. Long noncoding RNA TP73-AS1 targets microRNA-329-3p to regulate expression of the SMAD2 gene in human cervical cancer tissue and cell lines. Med. Sci. 2024, 25, 8131–8141. [Google Scholar] ceflawyersWebJan 19, 2024 · The downregulated DEGs located at the intracellular membrane organelle and nucleus, appeared to bind with RNA and catalytic enzymes, and mediate channel activity. The GO results were consistent … cefl dividend schedule 2020WebDownregulated genes in CD8 + TILs from patients with advanced stages were enriched in pathways related to T cell costimulation, adaptive immune response, cytokine secretion, … cef learning 1ere connexionWebIntroduction. Ovarian cancer is the most lethal of the gynecologic malignancies, with an estimated 200,000 cases and 125,000 deaths occurring annually worldwide. 1 Ovarian … cefl championship tableWebJun 6, 2024 · Finally, 6 upregulated DEGs (CST2, DRP2, CLEC5A, SCD, KIAA1211, DTL) and 6 downregulated DEGs (STAC2, BTNL9, CA4, CD300LG, GPIHBP1 and PIGR), … cef learning espace eleve*WebApr 11, 2024 · The MP-DEG PPI network comprised 69 nodes and 72 edges, from which 10 hub genes ( FASN, GCK, FGR, FBP1, GYS2, PNPLA3, MOGAT1, SLC27A2, PNPLA3, and ELOVL6) were identified. FASN was chosen as the key gene because it had the highest maximal clique centrality (MCC) score. GCK, FBP1, and FGR were selected as primary … cefl bowl 2022WebOct 10, 2024 · A tab-separated file containing the values for the network from STRING was imported into Cytoscape (continuous mapping for columns depended on the frequency of genes; default size of the column = 30.0; upregulated genes were red and downregulated genes were blue), which was applied to detect the potential interactions between these … cef leak