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Cst fam134b

WebJan 13, 2024 · FAM134B forms oligomers that are required for ER membrane scission and ER-phagy A. Endogenous FAM134B forms oligomers. FAM134B knockout (KO) or wild-type (WT) 293T cells were treated with 1 μM of Thapsigargin (Tg) for different time, and the cell lysates were prepared and analyzed by Western blot. WebFeb 21, 2024 · FAM134B controls ER turnover by specific binding to microtubule-associated protein 1 light chain 3B (MAP1LC3B), which in turn binds to the phagophore membrane …

Critical roles of FAM134B in ER-phagy and diseases

WebFAM134B contains a conserved LC3 interacting domain (LIR) that facilitates binding to LC3 and GABARAP family members and targets impaired ER to the autophagosome for degradation by ER-phagy (2). ... Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products ... WebFAM134B overexpression also ameliorated the AE-induced ultrastructural damage in neuronal mitochondria, decrease in mitochondrial membrane potential (mMP), cytochrome c (CytC) release and caspase-3 activation, while FAM134B downregulation induced the … ottw summer outfits https://ishinemarine.com

RCSB PDB - 7FB5: Crystal structure of FAM134B/GABARAP complex

WebAug 24, 2024 · Several ER surface receptors, including FAM134B, reticulon 3L (RTN3L), Sec62, and CCPG1, have been shown to contain conserved LC3-interacting regions (LIRs) that can act as specific autophagy receptors to allow portions of the larger ER network to be shunted to core autophagy pathways ( Khaminets et al., 2015; Fumagalli et al., 2016; … WebMay 30, 2024 · FAM134B, the first ER-phagy receptor to be identified, contains a reticulon-homology domain (RHD). FAM134B targets ER … WebFAM134B (E8Y9R) Rabbit mAb Cell Signaling Technology Monoclonal Antibody for studying FAM134B. Validated for WB, IP, IF. Highly specific and rigorously validated in-house, FAM134B (E8Y9R) Rabbit Monoclonal Antibody (CST #83414) is ready to ship. Go to your regional site? Would you like to visit your country specific website? YESNO ottw stock price

Entry - *613114 - RETICULOPHAGY REGULATOR 1; RETREG1

Category:FAM134B (E8Y9R) Rabbit mAb (#83414) Datasheet with Images …

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Cst fam134b

ER-phagy and human diseases Cell Death & Differentiation

WebCommunity School 134 is a NYC DOE public school in District 12, Bronx. WebOct 4, 2016 · FAM134B, the Selective Autophagy Receptor for Endoplasmic Reticulum Turnover, Inhibits Replication of Ebola Virus Strains Makona and Mayinga Abhilash I. Chiramel, Jonathan D. Dougherty, Vinod Nair, Shelly J. Robertson, Sonja M. Best

Cst fam134b

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WebNational Center for Biotechnology Information WebMar 29, 2024 · Fam134b is an oncogene that plays a crucial role in hepatocellular carcinoma via the Akt signaling pathway. FAM134B could play crucial roles in the …

WebDec 16, 2024 · The Fam134b gene, located on chromosome 5p15.1, was first identified as a regulator of the malignant phenotype and a downstream molecule of δ-catenin in esophageal squamous cell carcinoma (Tang et al., 2007). However, in colon cancer, FAM134B inhibits the migration of tumor cells (Kasem et al., 2014a, b). WebApr 18, 2024 · Here we report that in cancer cells, hypoxia-induced ER stress activates ER-phagy through the ER-phagy receptor FAM134B. Upon hypoxic stress, FAM134B is included in a complex with the ER chaperone ...

WebMay 17, 2024 · Four ER-resident proteins (FAM134B, CCPG1, SEC62, and RTN3) have been identified as ER-resident cargo receptors, which contain LC3-interacting regions. In this study, we identified an N … WebDec 14, 2024 · FAM134B has also been associated with different cancers, although its exact role remains elusive. We report here that the FAM134B gene encodes not one but …

WebJun 3, 2015 · These data demonstrate that FAM134B is an ER-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes (ER-phagy). Notably, this …

WebFAM134B Attenuates Seizure‑Induced Apoptosis and Endoplasmic Reticulum Stress in Hippocampal Neurons by Promoting Autophagy Nanchang Xie 1 · Yingjiao Li 1 · Cui Wang 2 · Yajun Lian 1 · Haifeng Zhang 1 · Yujuan Li 1 · Xianghe Meng 1 · Liyuan Du 1 ott workflowWebFam134b, supplied by Abcam, used in various techniques. Bioz Stars score: 92/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more ott wrdcWebNov 16, 2024 · FAM134B (also called JK-1, RETREG1), a member of the family with sequence similarity 134, was originally discovered as an oncogene in esophageal … rocky mountain sheds lykens paWebDec 31, 2024 · Department of the Treasury Internal Revenue Service Cincinnati, OH 45999-0039 Notice CP134B Tax period December 31, 2024 Notice Date January 8, 2024 … rocky mountain shedsWebApr 11, 2024 · Crucially, to confirm that endogenous FAM134B flux follows a similar trend to the overexpressed reporter, we looked at FAM134B localization in PDAC cells upon BafA1 treatment (Figure 4D). Indeed, FAM134B puncta accumulation after autophagy block indicates high basal turnover rate of the receptor in line with our observation with the … ottyan_twstWebOct 28, 2024 · In contrast, FAM134B may rather act as a tumor suppressor, since FAM134B mutations have been frequently found in colorectal adenocarcinoma, and esophageal squamous cell carcinoma [41, 43, 73]. ott wormWebFAM134B (family with sequence similarity 134, member B), also referred to as JK-1 and RETREG1, is a cis-Golgi endoplasmic reticulum (ER) transmembrane protein that plays a role in ER homeostasis and may … ott.x x-fronts